Reactome | RHO GTPases activate PKNs

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RHO GTPases activate PKNs Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10910804
displayName	RHO GTPases activate PKNs
eventOf	[Pathway:R-DME-195258] RHO GTPase Effectors - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DME-5623622] RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 - Drosophila melanogaster [Reaction:R-DME-5623632] RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 - Drosophila melanogaster [Reaction:R-DME-5623667] PDPK1 phosphorylates PKN1,2,3 - Drosophila melanogaster [Pathway:R-DME-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Drosophila melanogaster [Reaction:R-DME-5671737] p-T774-PKN1 binds CDC25C - Drosophila melanogaster [Reaction:R-DME-5671749] p-T774-PKN1 phosphorylates CDC25C - Drosophila melanogaster [Reaction:R-DME-75016] Association of p-S216-CDC25C with 14-3-3 proteins - Drosophila melanogaster [Reaction:R-DME-5671763] p-T774-PKN1 phosphorylates PPP1R14A - Drosophila melanogaster [Reaction:R-DME-5671772] p-T38-PPP1R14A binds MLCP - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-5625740] RHO GTPases activate PKNs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	RHO GTPases activate PKNs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5625740
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-DME-8848021] Signaling by PTK6 [Pathway:R-DME-5625900] RHO GTPases activate CIT [Pathway:R-DME-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(inferredTo)	[Pathway:R-HSA-5625740] RHO GTPases activate PKNs

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