Reactome | RHO GTPases activate PKNs

Schema > Pathway > Entries

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11049118
displayName	RHO GTPases activate PKNs
eventOf	[Pathway:R-DDI-195258] RHO GTPase Effectors - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DDI-5671737] p-T774-PKN1 binds CDC25C - Dictyostelium discoideum [Reaction:R-DDI-5671749] p-T774-PKN1 phosphorylates CDC25C - Dictyostelium discoideum [Reaction:R-DDI-75016] Association of p-S216-CDC25C with 14-3-3 proteins - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-5625740] RHO GTPases activate PKNs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RHO GTPases activate PKNs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5625740
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DDI-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-DDI-8848021] Signaling by PTK6
(inferredTo)	[Pathway:R-HSA-5625740] RHO GTPases activate PKNs

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