Reactome | RAB3IP stimulates nucleotide exchange on RAB8A

Schema > Reaction > Entries

RAB3IP stimulates nucleotide exchange on RAB8A Show undefined attributes

authored	[InstanceEdit:5620934] Rothfels, Karen, 2014-08-27
catalystActivity	[CatalystActivity:5623520] guanyl-nucleotide exchange factor activity of RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:5623522] Rothfels, Karen, 2014-09-12
dbId	5623521
displayName	RAB3IP stimulates nucleotide exchange on RAB8A
edited	[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
eventOf	[Pathway:R-HSA-5620916] VxPx cargo-targeting to cilium - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5623525] Cargo-carrying vesicles bud from the TGN - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-5623444] RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5623283] A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport [LiteratureReference:5617505] A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis [LiteratureReference:5617564] Functional dissection of Rab GTPases involved in primary cilium formation [LiteratureReference:5623298] Coordination of Rab8 and Rab11 in primary ciliogenesis [LiteratureReference:5623312] Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome [LiteratureReference:5623329] The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting [LiteratureReference:5623300] Crosstalk of Arf and Rab GTPases en route to cilia [LiteratureReference:5618172] The roles of evolutionarily conserved functional modules in cilia-related trafficking
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	RAB3IP stimulates nucleotide exchange on RAB8A
orthologousEvent	[Reaction:R-DME-5623521] RAB3IP stimulates nucleotide exchange on RAB8A - Drosophila melanogaster [Reaction:R-GGA-5623521] RAB3IP stimulates nucleotide exchange on RAB8A - Gallus gallus [Reaction:R-XTR-5623521] RAB3IP stimulates nucleotide exchange on RAB8A - Xenopus tropicalis [Reaction:R-DRE-5623521] RAB3IP stimulates nucleotide exchange on RAB8A - Danio rerio [Reaction:R-SSC-5623521] RAB3IP stimulates nucleotide exchange on RAB8A - Sus scrofa [Reaction:R-BTA-5623521] RAB3IP stimulates nucleotide exchange on RAB8A - Bos taurus [Reaction:R-CFA-5623521] RAB3IP stimulates nucleotide exchange on RAB8A - Canis familiaris [Reaction:R-RNO-5623521] RAB3IP stimulates nucleotide exchange on RAB8A - Rattus norvegicus [Reaction:R-MMU-5623521] RAB3IP stimulates nucleotide exchange on RAB8A - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-5623447] RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane]
precedingEvent	[Reaction:R-HSA-5623519] RAB3IP and RAB8A bind to the ciliary targeting complex - Homo sapiens
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10 [InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5623521
summation	[Summation:5623351] Once recruited to the ciliary targeting complex, RAB3IP/RABI...
systematicName	RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins activates RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins
updateTrackers	[UpdateTracker:9964666] Update Tracker - [Reaction:5623521] RAB3IP stimulates nucleotide exchange on RAB8A - v94:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9964666] Update Tracker - [Reaction:5623521] RAB3IP stimulates nucleotide exchange on RAB8A - v94:[modifyText]
(hasEvent)	[Pathway:R-HSA-5620916] VxPx cargo-targeting to cilium
(precedingEvent)	[BlackBoxEvent:R-HSA-5623525] Cargo-carrying vesicles bud from the TGN