RAB3IP stimulates nucleotide exchange on RAB8A

Stable Identifier
Reaction [transition]
Homo sapiens
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Once recruited to the ciliary targeting complex, RAB3IP/RABIN8 stimulates nucleotide exchange on RAB8A. Activated RAB8A is required for ciliogenesis and plays a role in mediating vesicle docking at the basal body, providing both lipid and protein content to the emerging cilium (Hattula et al, 2002; Knodler et al, 2010; Nachury et al, 2007; Wang et al, 2012; Westlake et al, 2011; Yoshimura et al, 2007; reviewed in Deretic, 2013; Sung and Leroux, 2013).

Literature References
PubMed ID Title Journal Year
24296415 The roles of evolutionarily conserved functional modules in cilia-related trafficking

Sung, CH, Leroux, MR

Nat. Cell Biol. 2013
17646400 Functional dissection of Rab GTPases involved in primary cilium formation

Barr, FA, Haas, AK, Egerer, J, Yoshimura, S, Fuchs, E

J. Cell Biol. 2007
20308558 Coordination of Rab8 and Rab11 in primary ciliogenesis

Das, A, Zhang, J, Zhang, X, Guo, W, Knödler, A, Feng, S, Peränen, J

Proc. Natl. Acad. Sci. U.S.A. 2010
12221131 A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport

Arffman, A, Hattula, K, Peränen, J, Furuhjelm, J

Mol. Biol. Cell 2002
21273506 Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Kirkpatrick, DS, Scheller, RH, Ervin, KE, Wright, KJ, Slusarski, DC, Nachury, MV, Westlake, CJ, Baye, LM, Sheffield, VC, Chalouni, C, Jackson, PK, Beck, JS, Phu, L

Proc. Natl. Acad. Sci. U.S.A. 2011
22983554 The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting

Deretic, D, Morita, Y, Mazelova, J, Wang, J

EMBO J. 2012
17574030 A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

Westlake, CJ, Loktev, AV, Zhang, Q, Sheffield, VC, Scheller, RH, Slusarski, DC, Nachury, MV, Jackson, PK, Peränen, J, Bazan, JF, Merdes, A

Cell 2007
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
Catalyst Activity

guanyl-nucleotide exchange factor activity of RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane]

Orthologous Events
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