Reactome | RAB3IP and RAB8A bind to the ciliary targeting complex

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RAB3IP and RAB8A bind to the ciliary targeting complex Show undefined attributes

authored	[InstanceEdit:5620934] Rothfels, Karen, 2014-08-27
category	binding
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:5623518] Rothfels, Karen, 2014-09-12
dbId	5623519
displayName	RAB3IP and RAB8A bind to the ciliary targeting complex
edited	[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
eventOf	[Pathway:R-HSA-5620916] VxPx cargo-targeting to cilium - Homo sapiens
followingEvent	[Reaction:R-HSA-5623521] RAB3IP stimulates nucleotide exchange on RAB8A - Homo sapiens
input	[Complex:R-HSA-5623437] RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] [Complex:R-HSA-5623440] RAB3IP:RAB8A:GDP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5623329] The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting [LiteratureReference:5623300] Crosstalk of Arf and Rab GTPases en route to cilia [LiteratureReference:5623312] Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome [LiteratureReference:5623283] A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport [LiteratureReference:5623298] Coordination of Rab8 and Rab11 in primary ciliogenesis [LiteratureReference:5623281] A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RAB3IP and RAB8A bind to the ciliary targeting complex
orthologousEvent	[Reaction:R-GGA-5623519] RAB3IP and RAB8A bind to the ciliary targeting complex - Gallus gallus [Reaction:R-XTR-5623519] RAB3IP and RAB8A bind to the ciliary targeting complex - Xenopus tropicalis [Reaction:R-DRE-5623519] RAB3IP and RAB8A bind to the ciliary targeting complex - Danio rerio [Reaction:R-SSC-5623519] RAB3IP and RAB8A bind to the ciliary targeting complex - Sus scrofa [Reaction:R-BTA-5623519] RAB3IP and RAB8A bind to the ciliary targeting complex - Bos taurus [Reaction:R-RNO-5623519] RAB3IP and RAB8A bind to the ciliary targeting complex - Rattus norvegicus [Reaction:R-MMU-5623519] RAB3IP and RAB8A bind to the ciliary targeting complex - Mus musculus
output	[Complex:R-HSA-5623444] RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane]
precedingEvent	[Reaction:R-HSA-5623513] ASAP1 stimulates GTPase activity of ARF4 - Homo sapiens
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10 [InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5623519
summation	[Summation:5623355] RAB8A is another small GTPase that is required for ciliogene...
systematicName	RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins binds RAB3IP:RAB8A:GDP forming RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins

Referrals

(hasEvent)	[Pathway:R-HSA-5620916] VxPx cargo-targeting to cilium
(precedingEvent)	[Reaction:R-HSA-5623521] RAB3IP stimulates nucleotide exchange on RAB8A

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