Reactome | SLC22A12 exchanges extracellular urate for cytosolic LACT

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SLC22A12 exchanges extracellular urate for cytosolic LACT Show undefined attributes

authored	[InstanceEdit:561229] Jassal, Bijay, 2010-03-31
catalystActivity	[CatalystActivity:561239] urate transmembrane transporter activity of SLC22A12 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:561229] Jassal, Bijay, 2010-03-31
crossReference	[DatabaseIdentifier:12667880] RHEA:72003 [DatabaseIdentifier:9958693] RHEA:72004
dbId	561253
diseaseReaction	[FailedReaction:R-HSA-5625210] Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT - Homo sapiens
displayName	SLC22A12 exchanges extracellular urate for cytosolic LACT
edited	[InstanceEdit:561229] Jassal, Bijay, 2010-03-31
eventOf	[Pathway:R-HSA-561048] Organic anion transport by SLC22 transporters - Homo sapiens
followingEvent	[Reaction:R-HSA-373867] BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29708] LACT [cytosol] [SimpleEntity:R-ALL-429056] urate [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:561226] Molecular identification of a renal urate anion exchanger that regulates blood urate levels [LiteratureReference:561250] Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SLC22A12 exchanges extracellular urate for cytosolic LACT URAT1 regulates urate levels in blood with exchange for organic anions
orthologousEvent	[Reaction:R-SSC-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Sus scrofa [Reaction:R-CFA-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Canis familiaris [Reaction:R-MMU-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Mus musculus [Reaction:R-BTA-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Bos taurus [Reaction:R-RNO-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Rattus norvegicus [Reaction:R-CEL-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Caenorhabditis elegans [Reaction:R-DME-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Drosophila melanogaster [Reaction:R-GGA-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Gallus gallus [Reaction:R-XTR-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Xenopus tropicalis [Reaction:R-DRE-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Danio rerio
output	[SimpleEntity:R-ALL-373863] LACT [extracellular region] [SimpleEntity:R-ALL-30034] urate [cytosol]
precedingEvent	[Reaction:R-HSA-373867] BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:706449] He, L, 2010-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-561253
summation	[Summation:561240] Urate is a naturally occurring product of purine metabolism ...
updateTrackers	[UpdateTracker:9784408] Update Tracker - [Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - v54:[modifyText] [UpdateTracker:9785691] Update Tracker - [Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - v51:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784408] Update Tracker - [Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - v54:[modifyText] [UpdateTracker:9785691] Update Tracker - [Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - v51:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5625210] Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT
(hasEvent)	[Pathway:R-HSA-561048] Organic anion transport by SLC22 transporters
(precedingEvent)	[Reaction:R-HSA-9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Reaction:R-HSA-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol [Reaction:R-HSA-373867] BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol [Reaction:R-HSA-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol [Reaction:R-HSA-8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol

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