SLC22A12 exchanges extracellular urate for cytosolic LACT

Stable Identifier
Reaction [transition]
Homo sapiens
URAT1 regulates urate levels in blood with exchange for organic anions
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Urate is a naturally occurring product of purine metabolism and is a scavenger of biological oxidants. Uric acid readily precipitates out of aqueous solutions causing gout and kidney stones. Due to this ability, changes in urate levels are implicated in numerous disease processes. The human gene SLC22A12 encodes urate transporter 1 (URAT1), predominantly expressed in the kidney and is involved in the regulation of blood urate levels. This transport can be trans-stimulated by organic anions such as L-lactate (LACT) (Enomoto et al. 2002). Defects in SLC22A12 result in idiopathic renal hypouricaemia (lack of blood urate) (Wakida et al. 2005).
Literature References
PubMed ID Title Journal Year
15634722 Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia

Kikuchi, Y, Kitamura, K, Ueda, O, Tazawa, M, Otagiri, M, Nonoguchi, H, Miyoshi, T, Kurihara, S, Matsuo, H, Oda, T, Wakida, N, Yoneta, Y, Endou, H, Adachi, M, Tomita, K, Hosoyamada, M, Oka, T, Tuyen, DG, Shimada, H

J Clin Endocrinol Metab 2005
12024214 Molecular identification of a renal urate anion exchanger that regulates blood urate levels

Kikuchi, Y, Shimokata, K, Cha, SH, Chairoungdua, A, Igarashi, T, Shigeta, Y, Ichida, K, Kanai, Y, Hosoya, T, Oda, T, Matsuo, H, Takeda, M, Kimura, H, Enomoto, A, Endou, H, Jutabha, P, Niwa, T, Hosoyamada, M, Sekine, T

Nature 2002
Catalyst Activity

urate transmembrane transporter activity of SLC22A12 [plasma membrane]

Orthologous Events
Cross References
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