Reactome | SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol

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SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:433709] Jassal, Bijay, 2009-08-25
catalystActivity	[CatalystActivity:434169] monocarboxylic acid transmembrane transporter activity of SLC16A7:EMB,SLC16A3,8:BSG [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:433709] Jassal, Bijay, 2009-08-25
crossReference	[DatabaseIdentifier:12667879] RHEA:29415 [DatabaseIdentifier:12667878] RHEA:71775 [DatabaseIdentifier:12667616] RHEA:64720 [DatabaseIdentifier:9861793] RHEA:29417 [DatabaseIdentifier:9861914] RHEA:64721
dbId	433698
displayName	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
eventOf	[Pathway:R-HSA-433692] Proton-coupled monocarboxylate transport - Homo sapiens
followingEvent	[Reaction:R-HSA-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Homo sapiens
input	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [DefinedSet:R-ALL-433683] MCT substrates [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:373885] Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter [LiteratureReference:433697] Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2 [LiteratureReference:445737] Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells [LiteratureReference:8959772] Monocarboxylic acid transport
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol MCTs mediate proton-coupled transport of monocarboxylates and ketone bodies
negativePrecedingEvent	[NegativePrecedingEvent:9963192] Futile Cycle: BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region
orthologousEvent	[Reaction:R-MMU-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - Mus musculus [Reaction:R-BTA-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - Bos taurus [Reaction:R-RNO-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - Rattus norvegicus [Reaction:R-CEL-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-DME-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-GGA-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - Gallus gallus [Reaction:R-DRE-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - Danio rerio
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [DefinedSet:R-ALL-433686] MCT substrates [cytosol]
precedingEvent	[Reaction:R-HSA-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-433698
summation	[Summation:433700] Four members of the SLC16A gene family encode classical mono...
updateTrackers	[UpdateTracker:9785766] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v51:[modifyText] [UpdateTracker:9784237] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v54:[modifyText] [UpdateTracker:9777741] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v69:[removeLiteratureReference] [UpdateTracker:9781582] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v60:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785766] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v51:[modifyText] [UpdateTracker:9784237] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v54:[modifyText] [UpdateTracker:9777741] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v69:[removeLiteratureReference] [UpdateTracker:9781582] Update Tracker - [Reaction:433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - v60:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-433692] Proton-coupled monocarboxylate transport
(precedingEvent)	[Reaction:R-HSA-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT [NegativePrecedingEvent:9963195] Futile Cycle: SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol

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