Reactome | SLC22A12 exchanges extracellular urate for cytosolic LACT

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SLC22A12 exchanges extracellular urate for cytosolic LACT Show undefined attributes

catalystActivity	[CatalystActivity:10856892] urate transmembrane transporter activity of SLC22A12 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10856894
displayName	SLC22A12 exchanges extracellular urate for cytosolic LACT
eventOf	[Pathway:R-DME-561048] Organic anion transport by SLC22 transporters - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-373867] BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Homo sapiens
input	[SimpleEntity:R-ALL-29708] LACT [cytosol] [SimpleEntity:R-ALL-429056] urate [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC22A12 exchanges extracellular urate for cytosolic LACT URAT1 regulates urate levels in blood with exchange for organic anions
output	[SimpleEntity:R-ALL-373863] LACT [extracellular region] [SimpleEntity:R-ALL-30034] urate [cytosol]
precedingEvent	[Reaction:R-DME-373867] BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-DME-8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-561253
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-561048] Organic anion transport by SLC22 transporters
(precedingEvent)	[Reaction:R-DME-373867] BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol [Reaction:R-DME-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol [Reaction:R-DME-8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol [Reaction:R-DME-9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Reaction:R-DME-433698] SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol
(inferredTo)	[Reaction:R-HSA-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT

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