Expression of CEBPA

Stable Identifier
R-HSA-560491
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The CEBPA gene is transcribed to yield mRNA and the mRNA is translated to yield protein.

The PPARG:RXRA heterodimer bound to fatty acids activates transcription of the CEBPA gene. In mouse the Pparg:Rxra heterodimer binds the promoter of the Cebpa gene (Lefterova et al. 2008).

The activation of expression of CEBPA by EBF1 is inferred from mouse where Ebf1 directly binds one site in the Cebpa promoter and activates transcription of the Cebpa gene.

As inferred from mouse 3T3-L1 cells, Wnt-1 and Wnt-10b inhibit expression of CEBPA through stabillization of beta-Catenin. Wnt-10b is probably the actual regulator in vivo.

As inferred from mouse, TNF-alpha inhibits expression of CEBPA in pre-adipocytes.

As inferred from mouse, TGF-beta inhibits expression of CEPBA in preadipocytes.

Literature References
PubMed ID Title Journal Year
16380219 Identification of novel PPARgamma target genes in primary human adipocytes

Dean, NM, Koo, S, Kim, Y, Marcusson, EG, Kang, X, Perera, RJ, White, N

Gene 2006
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