OCT1 transports organic cations into hepatic cells

Stable Identifier
R-HSA-549129
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human gene SLC22A1 expresses the organic cation transporter 1 (OCT1) mainly in the liver. It can mediate the reversible transport of a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (Zhang L et al, 1998; Gorboulev V et al, 1997).

Literature References
PubMed ID Title Journal Year
9655880 Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa)

Zhang, L, Schaner, ME, Giacomini, KM

J Pharmacol Exp Ther 1998
9260930 Cloning and characterization of two human polyspecific organic cation transporters

Gorboulev, V, Ulzheimer, JC, Akhoundova, A, Ulzheimer-Teuber, I, Karbach, U, Quester, S, Baumann, C, Lang, F, Busch, AE, Koepsell, H

DNA Cell Biol 1997
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
organic cation transmembrane transporter activity of OCT1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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