Reactome | Mitochondrial translation termination

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Mitochondrial translation termination Show undefined attributes

authored	[InstanceEdit:5389860] May, Bruce, 2014-04-30
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:5419278] May, Bruce, 2014-05-03
dbId	5419276
displayName	Mitochondrial translation termination
doi	10.3180/R-HSA-5419276.5
edited	[InstanceEdit:5389860] May, Bruce, 2014-04-30
eventOf	[Pathway:R-HSA-5368287] Mitochondrial translation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:383674] mitochondrial translational termination
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Homo sapiens [BlackBoxEvent:R-HSA-5419271] 55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Homo sapiens [Reaction:R-HSA-9937415] MTRF1 and GTP bind 55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA at P-site:tRNA at E-site - Homo sapiens [BlackBoxEvent:R-HSA-9937394] 55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Homo sapiens [Reaction:R-HSA-5419281] MRRF binds 55S ribosome:mRNA:tRNA - Homo sapiens [Reaction:R-HSA-5419277] GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA - Homo sapiens [Reaction:R-HSA-5419273] Hydrolysis of GTP and dissociation of 28S and 39S subunits - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2014-12-08
literatureReference	[LiteratureReference:5423521] Mechanism of protein biosynthesis in mammalian mitochondria [LiteratureReference:5432605] Translation termination in human mitochondrial ribosomes [LiteratureReference:5432630] Termination of protein synthesis in mammalian mitochondria [LiteratureReference:5432610] mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Mitochondrial translation termination
orthologousEvent	[Pathway:R-CFA-5419276] Mitochondrial translation termination - Canis familiaris [Pathway:R-CEL-5419276] Mitochondrial translation termination - Caenorhabditis elegans [Pathway:R-DME-5419276] Mitochondrial translation termination - Drosophila melanogaster [Pathway:R-GGA-5419276] Mitochondrial translation termination - Gallus gallus [Pathway:R-XTR-5419276] Mitochondrial translation termination - Xenopus tropicalis [Pathway:R-DRE-5419276] Mitochondrial translation termination - Danio rerio [Pathway:R-SSC-5419276] Mitochondrial translation termination - Sus scrofa [Pathway:R-BTA-5419276] Mitochondrial translation termination - Bos taurus [Pathway:R-RNO-5419276] Mitochondrial translation termination - Rattus norvegicus [Pathway:R-MMU-5419276] Mitochondrial translation termination - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5621503] Chrzanowska-Lightowlers, Zofia M A, 2014-08-29 [InstanceEdit:5624178] Spremulli, Linda L, 2014-09-20 [InstanceEdit:9939586] Matthews, Lisa, 2025-03-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5419276
summation	[Summation:5487097] Translation is terminated for 11 of the 13 mitochondrially e...
updateTrackers	[UpdateTracker:9953560] Update Tracker - [Pathway:5419276] Mitochondrial translation termination - v93:[modifyText, removeHasEvent] [UpdateTracker:9785639] Update Tracker - [Pathway:5419276] Mitochondrial translation termination - v51:[modifyText, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9953560] Update Tracker - [Pathway:5419276] Mitochondrial translation termination - v93:[modifyText, removeHasEvent] [UpdateTracker:9785639] Update Tracker - [Pathway:5419276] Mitochondrial translation termination - v51:[modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-5368287] Mitochondrial translation

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