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Entries
MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
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authored
[InstanceEdit:5389860] May, Bruce, 2014-04-30
category
binding
compartment
[Compartment:5460] mitochondrial matrix
[Compartment:70616] mitochondrial inner membrane
created
[InstanceEdit:5419278] May, Bruce, 2014-05-03
dbId
5419264
displayName
MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
edited
[InstanceEdit:5389860] May, Bruce, 2014-04-30
eventOf
[Pathway:R-HSA-5419276] Mitochondrial translation termination - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-5419271] 55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Homo sapiens
input
[Complex:R-HSA-9941868] 55S ribosome:mRNA (UAA,UAG stop codon):peptidyl-tRNA at P-site [mitochondrial inner membrane]
[SimpleEntity:R-ALL-113573] GTP [mitochondrial matrix]
[DefinedSet:R-HSA-5432633] MTRF1L, ICT1 [mitochondrial matrix]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5432614] HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG
[LiteratureReference:5432610] mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
orthologousEvent
[Reaction:R-CFA-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Canis familiaris
[Reaction:R-CEL-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Caenorhabditis elegans
[Reaction:R-DME-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Drosophila melanogaster
[Reaction:R-GGA-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Gallus gallus
[Reaction:R-XTR-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Xenopus tropicalis
[Reaction:R-DRE-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Danio rerio
[Reaction:R-SSC-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Sus scrofa
[Reaction:R-BTA-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Bos taurus
[Reaction:R-RNO-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Rattus norvegicus
[Reaction:R-MMU-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Mus musculus
output
[Complex:R-HSA-5419280] 55S ribosome:mRNA (UAA,UAG stop codon):peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane]
precedingEvent
[Reaction:R-HSA-5419279] Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2014-09-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5621503] Chrzanowska-Lightowlers, Zofia M A, 2014-08-29
[InstanceEdit:5624178] Spremulli, Linda L, 2014-09-20
[InstanceEdit:9953420] May, Bruce, 2025-06-02
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5419264
summation
[Summation:5487082] MTRF1L (mtRF1a) binds the stop codons UAA and UAG of the mRN...
updateTrackers
[UpdateTracker:9785903] Update Tracker - [Reaction:5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - v51:[modifyText]
[UpdateTracker:9953701] Update Tracker - [Reaction:5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - v93:[add_removeInput]
[UpdateTracker:9939808] Update Tracker - [Reaction:5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - v92:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9785903] Update Tracker - [Reaction:5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - v51:[modifyText]
[UpdateTracker:9953701] Update Tracker - [Reaction:5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - v93:[add_removeInput]
[UpdateTracker:9939808] Update Tracker - [Reaction:5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - v92:[addLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-5419276] Mitochondrial translation termination
(precedingEvent)
[BlackBoxEvent:R-HSA-5419271] 55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed
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