Reactome | 55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed

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55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed Show undefined attributes

authored	[InstanceEdit:9937408] May, Bruce, 2025-01-29
category	uncertain
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9937368] May, Bruce, 2025-01-31
dbId	9937394
displayName	55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed
edited	[InstanceEdit:9937408] May, Bruce, 2025-01-29
eventOf	[Pathway:R-HSA-5419276] Mitochondrial translation termination - Homo sapiens
followingEvent	[Reaction:R-HSA-5419281] MRRF binds 55S ribosome:mRNA:tRNA - Homo sapiens
input	[Complex:R-HSA-9937391] 55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA:tRNA:MTRF1:GTP [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9937462] Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control [LiteratureReference:9937463] Human mitochondria require mtRF1 for translation termination at non-canonical stop codons [LiteratureReference:9937385] Molecular basis of translation termination at noncanonical stop codons in human mitochondria
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed
orthologousEvent	[BlackBoxEvent:R-CEL-9937394] 55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Caenorhabditis elegans [BlackBoxEvent:R-DME-9937394] 55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Drosophila melanogaster [BlackBoxEvent:R-GGA-9937394] 55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Gallus gallus [BlackBoxEvent:R-SSC-9937394] 55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Sus scrofa [BlackBoxEvent:R-BTA-9937394] 55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Bos taurus [BlackBoxEvent:R-RNO-9937394] 55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Rattus norvegicus [BlackBoxEvent:R-MMU-9937394] 55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Mus musculus
output	[Complex:R-HSA-9937379] 55S ribosome:MT-CO1,MT-ND6 mRNA:tRNA [mitochondrial inner membrane] [SimpleEntity:R-ALL-113525] GDP [mitochondrial matrix] [DefinedSet:R-HSA-9937420] MT-CO1,MT-ND6 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-HSA-5432599] MTRF1 [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9937415] MTRF1 and GTP bind 55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA at P-site:tRNA at E-site - Homo sapiens
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9941871] Filipovska, Aleksandra, 2025-03-11
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9937394
summation	[Summation:9937457] MTRF1 terminates translation at the noncanonical codons AGA,...

Referrals

(hasEvent)	[Pathway:R-HSA-5419276] Mitochondrial translation termination
(precedingEvent)	[Reaction:R-HSA-5419281] MRRF binds 55S ribosome:mRNA:tRNA