Reactome | Mitochondrial translation termination

Schema > Pathway > Entries

Mitochondrial translation termination Show undefined attributes

compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224667
displayName	Mitochondrial translation termination
eventOf	[Pathway:R-RNO-5368287] Mitochondrial translation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:383674] mitochondrial translational termination
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Rattus norvegicus [BlackBoxEvent:R-RNO-5419271] 55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Rattus norvegicus [Reaction:R-RNO-9937415] MTRF1 and GTP bind 55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA at P-site:tRNA at E-site - Rattus norvegicus [BlackBoxEvent:R-RNO-9937394] 55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Rattus norvegicus [Reaction:R-RNO-5419281] MRRF binds 55S ribosome:mRNA:tRNA - Rattus norvegicus [Reaction:R-RNO-5419273] Hydrolysis of GTP and dissociation of 28S and 39S subunits - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-5419276] Mitochondrial translation termination - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Mitochondrial translation termination
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5419276
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5368287] Mitochondrial translation
(inferredTo)	[Pathway:R-HSA-5419276] Mitochondrial translation termination