Reactome | 55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP

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55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP Show undefined attributes

authored	[InstanceEdit:5389860] May, Bruce, 2014-04-30
category	omitted
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:5419278] May, Bruce, 2014-05-03
dbId	5419271
displayName	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP
edited	[InstanceEdit:5389860] May, Bruce, 2014-04-30
eventOf	[Pathway:R-HSA-5419276] Mitochondrial translation termination - Homo sapiens
followingEvent	[Reaction:R-HSA-5419281] MRRF binds 55S ribosome:mRNA:tRNA - Homo sapiens
input	[Complex:R-HSA-5419280] 55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5432606] A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome [LiteratureReference:5423521] Mechanism of protein biosynthesis in mammalian mitochondria [LiteratureReference:5432614] HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG [LiteratureReference:5432610] mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG [LiteratureReference:5624191] Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP
orthologousEvent	[BlackBoxEvent:R-CEL-5419271] 55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP - Caenorhabditis elegans [BlackBoxEvent:R-DME-5419271] 55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP - Drosophila melanogaster [BlackBoxEvent:R-GGA-5419271] 55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP - Gallus gallus [BlackBoxEvent:R-SSC-5419271] 55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP - Sus scrofa [BlackBoxEvent:R-BTA-5419271] 55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP - Bos taurus [BlackBoxEvent:R-CFA-5419271] 55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP - Canis familiaris [BlackBoxEvent:R-RNO-5419271] 55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP - Rattus norvegicus [BlackBoxEvent:R-MMU-5419271] 55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP - Mus musculus
output	[Complex:R-HSA-5419262] 55S ribosome:mRNA:tRNA [mitochondrial inner membrane] [SimpleEntity:R-ALL-113525] GDP [mitochondrial matrix] [DefinedSet:R-HSA-5432633] MTRF1L, ICT1 [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix] [OtherEntity:R-ALL-5419287] polypeptide [mitochondrial inner membrane]
precedingEvent	[Reaction:R-HSA-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Homo sapiens
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5621503] Chrzanowska-Lightowlers, Zofia M A, 2014-08-29 [InstanceEdit:5624178] Spremulli, Linda L, 2014-09-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5419271
summation	[Summation:5432600] Binding of the MTRF1L (MTRF1a) termination factor triggers h...

Referrals

(hasEvent)	[Pathway:R-HSA-5419276] Mitochondrial translation termination
(precedingEvent)	[Reaction:R-HSA-5419281] MRRF binds 55S ribosome:mRNA:tRNA

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