Reactome | processing defective Hh variants are degraded by the proteasome

Schema > BlackBoxEvent > Entries

processing defective Hh variants are degraded by the proteasome Show undefined attributes

authored	[InstanceEdit:5358461] Rothfels, Karen, 2014-03-28
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5387393] Rothfels, Karen, 2014-04-29
dbId	5387392
disease	[Disease:5358398] holoprosencephaly
displayName	processing defective Hh variants are degraded by the proteasome
edited	[InstanceEdit:5490367] D'Eustachio, Peter, 2014-05-19
entityFunctionalStatus	[EntityFunctionalStatus:9630079] gain_of_function of ub-SHH variants [cytosol]
eventOf	[Pathway:R-HSA-5362768] Hh mutants are degraded by ERAD - Homo sapiens
input	[CandidateSet:R-HSA-5387369] ub-SHH variants [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5358239] Processing and turnover of the Hedgehog protein in the endoplasmic reticulum [LiteratureReference:5359146] Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	processing defective Hh variants are degraded by the proteasome
output	[DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[Reaction:R-HSA-5387389] Hh processing variants are translocated to the cytosol in a VCP-dependent manner - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5387392
summation	[Summation:5387380] After retrotranslocation to the cytosol, processing-defectiv...

Referrals

(hasEvent)

[Pathway:R-HSA-5362768] Hh mutants are degraded by ERAD

Cite Us!