Reactome | Hh processing variants are ubiquitinated

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Hh processing variants are ubiquitinated Show undefined attributes

authored	[InstanceEdit:5483111] Rothfels, Karen, 2014-05-16
catalystActivity	[CatalystActivity:5483235] ubiquitin-protein transferase activity of SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:5483240] Rothfels, Karen, 2014-05-16
dbId	5483238
disease	[Disease:5358398] holoprosencephaly
displayName	Hh processing variants are ubiquitinated
edited	[InstanceEdit:5490367] D'Eustachio, Peter, 2014-05-19
entityFunctionalStatus	[EntityFunctionalStatus:9630074] gain_of_function of SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
eventOf	[Pathway:R-HSA-5362768] Hh mutants are degraded by ERAD - Homo sapiens
followingEvent	[Reaction:R-HSA-5387389] Hh processing variants are translocated to the cytosol in a VCP-dependent manner - Homo sapiens
input	[Complex:R-HSA-5387378] SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5358239] Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hh processing variants are ubiquitinated
output	[Complex:R-HSA-5483239] ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-5387386] Hh processing variants are recruited to SEL1:SYVN at the ER membrane - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5483238
summation	[Summation:5483236] Processing-defective SHH variants are ubiquitinated by SYVN1...

Referrals

(hasEvent)	[Pathway:R-HSA-5362768] Hh mutants are degraded by ERAD
(precedingEvent)	[Reaction:R-HSA-5387389] Hh processing variants are translocated to the cytosol in a VCP-dependent manner