Reactome | MSH2:MSH3 exchanges ADP for ATP

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MSH2:MSH3 exchanges ADP for ATP Show undefined attributes

authored	[InstanceEdit:5358529] May, B, 2014-03-28
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5358925] May, Bruce, 2014-04-05
dbId	5358919
displayName	MSH2:MSH3 exchanges ADP for ATP
edited	[InstanceEdit:5358908] May, Bruce, 2014-04-05
eventOf	[Pathway:R-HSA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) - Homo sapiens
followingEvent	[Reaction:R-HSA-5358519] MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Homo sapiens
inferredFrom	[Reaction:R-HSA-5358912] MSH2:MSH6 exchanges ADP for ATP - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-5358532] MSH2:MSH3:ADP:DNA containing IDL of 2 bases or more [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5358581] ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair [LiteratureReference:5358604] Reconstitution of 5'-directed human mismatch repair in a purified system
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MSH2:MSH3 exchanges ADP for ATP
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-5358910] MSH2:MSH3:ATP:DNA containing IDL of 2 bases or more [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5358513] MSH2:MSH3 binds insertion/deletion loop of 2 bases or more - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5358919
summation	[Summation:5358922] After binding a mismatch, the MSH2:MSH3 (MutSbeta) heterodim...

Referrals

(hasEvent)	[Pathway:R-HSA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
(precedingEvent)	[Reaction:R-HSA-5358519] MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA
(inferredTo)	[Reaction:R-HSA-5358912] MSH2:MSH6 exchanges ADP for ATP

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