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Schema
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Reaction
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Entries
MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA
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authored
[InstanceEdit:5358529] May, B, 2014-03-28
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5358520] May, Bruce, 2014-03-29
dbId
5358519
displayName
MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA
edited
[InstanceEdit:5358529] May, B, 2014-03-28
eventOf
[Pathway:R-HSA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) - Homo sapiens
followingEvent
[Reaction:R-HSA-5358512] MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more - Homo sapiens
inferredFrom
[Reaction:R-HSA-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Homo sapiens
input
[Complex:R-HSA-5357522] MLH1:PMS2 [nucleoplasm]
[Complex:R-HSA-5358910] MSH2:MSH3:ATP:DNA containing IDL of 2 bases or more [nucleoplasm]
[Complex:R-HSA-68440] PCNA homotrimer [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:5358638] hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci
[LiteratureReference:5358926] Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutL? endonuclease activation
[LiteratureReference:5358917] MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta
[LiteratureReference:5358882] Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA
MutSbeta recruits MutLalpha to mismatch and interacts with PCNA
output
[Complex:R-HSA-5358523] MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm]
precedingEvent
[Reaction:R-HSA-5358919] MSH2:MSH3 exchanges ADP for ATP - Homo sapiens
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5358519
summation
[Summation:5358913] After being activated by an insertion/deletion loop (IDL), M...
Referrals
(hasEvent)
[Pathway:R-HSA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
(precedingEvent)
[Reaction:R-HSA-5358512] MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more
(inferredTo)
[Reaction:R-HSA-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA
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