Reactome | EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch

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EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch Show undefined attributes

catalystActivity	[CatalystActivity:10287901] 5'-3' exonuclease activity of EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10287903
displayName	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch
eventOf	[Pathway:R-CFA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5358579] DNA polymerase delta polymerizes DNA across single stranded gap - Canis familiaris
inferredFrom	[BlackBoxEvent:R-HSA-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Homo sapiens
input	[Complex:R-CFA-5358633] EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] [Complex:R-CFA-68462] RPA heterotrimer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch
output	[Complex:R-CFA-5358538] RPA:DNA containing single strand gap [nucleoplasm]
precedingEvent	[Reaction:R-CFA-5358597] EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) - Canis familiaris
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-5358599
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
(precedingEvent)	[Reaction:R-CFA-5358579] DNA polymerase delta polymerizes DNA across single stranded gap
(inferredTo)	[BlackBoxEvent:R-HSA-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch

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