Reactome | MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA

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MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA Show undefined attributes

authored	[InstanceEdit:5358529] May, B, 2014-03-28
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5358520] May, Bruce, 2014-03-29
dbId	5358510
displayName	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA
edited	[InstanceEdit:5358529] May, B, 2014-03-28
eventOf	[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Homo sapiens
followingEvent	[Reaction:R-HSA-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch - Homo sapiens
input	[Complex:R-HSA-5357522] MLH1:PMS2 [nucleoplasm] [Complex:R-HSA-5358934] MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] [Complex:R-HSA-68440] PCNA homotrimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5358590] hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA [LiteratureReference:5358632] DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes [LiteratureReference:5358638] hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci [LiteratureReference:5358580] Human mismatch repair: reconstitution of a nick-directed bidirectional reaction [LiteratureReference:5358604] Reconstitution of 5'-directed human mismatch repair in a purified system [LiteratureReference:5358667] PCNA function in the activation and strand direction of MutL? endonuclease in mismatch repair [LiteratureReference:5358850] The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair [LiteratureReference:5358848] Mismatch Repair proteins are recruited to replicating DNA through interaction with Proliferating Cell Nuclear Antigen (PCNA) [LiteratureReference:5358903] Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes [LiteratureReference:5358882] Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates [LiteratureReference:5358917] MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta [LiteratureReference:5358581] ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA MutSalpha binds ATP and recruits MutLalpha to mismatch
orthologousEvent	[Reaction:R-HSA-5358519] MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Homo sapiens [Reaction:R-MMU-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Mus musculus [Reaction:R-PFA-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Plasmodium falciparum [Reaction:R-SCE-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Saccharomyces cerevisiae [Reaction:R-SPO-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Schizosaccharomyces pombe [Reaction:R-DDI-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Dictyostelium discoideum [Reaction:R-DME-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Drosophila melanogaster [Reaction:R-GGA-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Gallus gallus [Reaction:R-SSC-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Sus scrofa [Reaction:R-BTA-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Bos taurus [Reaction:R-CFA-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Canis familiaris [Reaction:R-RNO-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Rattus norvegicus
output	[Complex:R-HSA-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5358912] MSH2:MSH6 exchanges ADP for ATP - Homo sapiens [Reaction:R-HSA-5444523] Formation of MSH1:PMS2 Complex - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5358510
summation	[Summation:5358880] After being activated by a mismatch, MSH2:MSH6 (MutSalpha) r...
updateTrackers	[UpdateTracker:9984647] Update Tracker - [Reaction:5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - v96:[removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9984647] Update Tracker - [Reaction:5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - v96:[removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
(precedingEvent)	[Reaction:R-HSA-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch

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