Reactome | MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more

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MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more Show undefined attributes

authored	[InstanceEdit:5358529] May, B, 2014-03-28
catalystActivity	[CatalystActivity:5358530] endonuclease activity of MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5358520] May, Bruce, 2014-03-29
dbId	5358512
displayName	MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more
edited	[InstanceEdit:5358529] May, B, 2014-03-28
eventOf	[Pathway:R-HSA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) - Homo sapiens
followingEvent	[Reaction:R-HSA-5358545] EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) - Homo sapiens
inferredFrom	[Reaction:R-HSA-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch - Homo sapiens
input	[Complex:R-HSA-5358523] MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5358604] Reconstitution of 5'-directed human mismatch repair in a purified system [LiteratureReference:5358675] Endonucleolytic function of MutLalpha in human mismatch repair
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more
output	[Complex:R-HSA-5358515] MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5358519] MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5358512
summation	[Summation:5358929] The latent endonuclease activity of MLH1:PMS2 (MutLalpha) is...

Referrals

(hasEvent)	[Pathway:R-HSA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
(precedingEvent)	[Reaction:R-HSA-5358545] EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha)
(inferredTo)	[Reaction:R-HSA-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch

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