Reactome | MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]

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MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:5358509] endonuclease activity of MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-HSA-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch - Homo sapiens
created	[InstanceEdit:5358520] May, Bruce, 2014-03-29
dbId	5358511
displayName	MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
hasComponent	[OtherEntity:R-ALL-5358514] DNA containing mismatch or 1-2 base IDL [nucleoplasm] [Complex:R-HSA-5357522] MLH1:PMS2 [nucleoplasm] [Complex:R-HSA-5358531] MSH2:MSH6:ATP [nucleoplasm] [Complex:R-HSA-68440] PCNA homotrimer [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Mus musculus [Complex:R-RNO-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Canis familiaris [Complex:R-BTA-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Bos taurus [Complex:R-SSC-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Sus scrofa [Complex:R-DRE-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Danio rerio [Complex:R-GGA-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Gallus gallus [Complex:R-DME-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Caenorhabditis elegans [Complex:R-DDI-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Dictyostelium discoideum [Complex:R-SPO-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Schizosaccharomyces pombe [Complex:R-SCE-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Saccharomyces cerevisiae [Complex:R-PFA-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Plasmodium falciparum
isChimeric	false
literatureReference	[LiteratureReference:5358590] hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA
maxDepth	3
modified	[InstanceEdit:5358935] May, Bruce, 2014-04-05
name	MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch MutLalpha:MutSalpha:ATP:PCNA:DNA with 1-2 base mismatch
producedByEvent	[Reaction:R-HSA-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5358511

Referrals

(input)	[Reaction:R-HSA-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch
(physicalEntity)	[CatalystActivity:5358509] endonuclease activity of MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(output)	[Reaction:R-HSA-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA

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