Reactome | MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10054303] endonuclease activity of MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-RNO-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch - Rattus norvegicus
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10054298
displayName	MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
hasComponent	[OtherEntity:R-ALL-5358514] DNA containing mismatch or 1-2 base IDL [nucleoplasm] [Complex:R-RNO-5357522] MLH1:PMS2 [nucleoplasm] [Complex:R-RNO-5358531] MSH2:MSH6:ATP [nucleoplasm] [Complex:R-RNO-68440] PCNA homotrimer [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Homo sapiens
name	MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch
producedByEvent	[Reaction:R-RNO-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5358511
summation	[Summation:9864367] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-RNO-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch
(physicalEntity)	[CatalystActivity:10054303] endonuclease activity of MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(output)	[Reaction:R-RNO-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA
(inferredTo)	[Complex:R-HSA-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]