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MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
Stable Identifier
R-HSA-5358511
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MutLalpha:MutSalpha:ATP:PCNA:DNA with 1-2 base mismatch
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Mismatch Repair (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Homo sapiens)
MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Homo sapiens)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Homo sapiens)
MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11809883
hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA
Raedle, J
,
Zeuzem, S
,
Brieger, A
,
Trojan, J
,
Plotz, G
Nucleic Acids Res.
2002
Participants
components
DNA containing mismatch or 1-2 base IDL [nucleoplasm]
MLH1:PMS2 [nucleoplasm]
(Homo sapiens)
MSH2:MSH6:ATP [nucleoplasm]
(Homo sapiens)
PCNA homotrimer [nucleoplasm]
(Homo sapiens)
Participates
as an input of
MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Homo sapiens)
as an output of
MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)
Inferred To
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Bos taurus)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Caenorhabditis elegans)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Canis familiaris)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Danio rerio)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Dictyostelium discoideum)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Drosophila melanogaster)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Gallus gallus)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Mus musculus)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Plasmodium falciparum)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Rattus norvegicus)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Saccharomyces cerevisiae)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Schizosaccharomyces pombe)
MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(Sus scrofa)
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