Reactome | MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10287878] endonuclease activity of MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-CFA-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10287863
displayName	MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
hasComponent	[OtherEntity:R-ALL-5358514] DNA containing mismatch or 1-2 base IDL [nucleoplasm] [Complex:R-CFA-5357522] MLH1:PMS2 [nucleoplasm] [Complex:R-CFA-5358531] MSH2:MSH6:ATP [nucleoplasm] [Complex:R-CFA-68440] PCNA homotrimer [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] - Homo sapiens
maxDepth	3
name	MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch
producedByEvent	[Reaction:R-CFA-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-5358511
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-CFA-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch
(physicalEntity)	[CatalystActivity:10287878] endonuclease activity of MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
(output)	[Reaction:R-CFA-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA
(inferredTo)	[Complex:R-HSA-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]

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