Reactome | DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2

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DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 Show undefined attributes

authored	[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
catalystActivity	[CatalystActivity:5358474] diphthine methyl ester synthase activity of DPH5 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643414] diphthine synthase activity of DPH5 [cytosol] The post-translational trimethylation of diphthamide studied in vitro
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
dbId	5358484
displayName	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2
edited	[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
eventOf	[Pathway:R-HSA-5358493] Synthesis of diphthamide-EEF2 - Homo sapiens
followingEvent	[Reaction:R-HSA-5367022] DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-71284] AdoMet [cytosol] [EntityWithAccessionedSequence:R-HSA-5358478] aminocarboxypropyl EEF2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5308144] Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2 [LiteratureReference:5358481] DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae [LiteratureReference:5358482] The post-translational trimethylation of diphthamide studied in vitro
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2
orthologousEvent	[Reaction:R-PFA-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Plasmodium falciparum [Reaction:R-SCE-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Saccharomyces cerevisiae [Reaction:R-SPO-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Schizosaccharomyces pombe [Reaction:R-DDI-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Dictyostelium discoideum [Reaction:R-CEL-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Caenorhabditis elegans [Reaction:R-DME-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Drosophila melanogaster [Reaction:R-GGA-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Gallus gallus [Reaction:R-XTR-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Xenopus tropicalis [Reaction:R-DRE-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Danio rerio [Reaction:R-SSC-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Sus scrofa [Reaction:R-BTA-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Bos taurus [Reaction:R-CFA-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Canis familiaris [Reaction:R-RNO-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Rattus norvegicus [Reaction:R-MMU-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Mus musculus
output	4 × [SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [EntityWithAccessionedSequence:R-HSA-5367025] Me-diphthine EEF2 [cytosol]
precedingEvent	[Reaction:R-HSA-5358494] DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5643867] Liu, Shihui, 2014-11-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5358484
summation	[Summation:5358477] Cytosolic diphthamide biosynthesis protein 5 (DPH5) transfer...

Referrals

(precedingEvent)	[Reaction:R-HSA-5367022] DPH7 hydrolyzes a methyl group on Me-diphthine EEF2
(hasEvent)	[Pathway:R-HSA-5358493] Synthesis of diphthamide-EEF2

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