Cytosolic diphthamide biosynthesis protein 5 (DPH5) transfer...

created [InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
dbId 5358477
displayName Cytosolic diphthamide biosynthesis protein 5 (DPH5) transfer...
modified [InstanceEdit:5643727] D'Eustachio, Peter, 2014-11-17
schemaClass Summation
text Cytosolic diphthamide biosynthesis protein 5 (DPH5) transfers four methyl groups from S-adenosylmethionine (AdoMet) to elongation factor 2 (EEF2) whose histidine residue at position 715 has been conjugated with a 3-amino 3-carboxypropyl group, forming methylated diphthine EEF2 and S-adenosylhomocysteine (AdoHcy). DPH5 activity has been identified in cells of diverse eukaryotic species including humans and has been characterized in detail in budding yeast (Liu et al. 2004; Matteakis et al. 1992; Moehring & Moehring 1988).
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