Reactome | DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2

Schema > Reaction > Entries

DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 Show undefined attributes

catalystActivity	[CatalystActivity:11095526] diphthine methyl ester synthase activity of DPH5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11095528
displayName	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2
eventOf	[Pathway:R-SCE-5358493] Synthesis of diphthamide-EEF2 - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-71284] AdoMet [cytosol] [EntityWithAccessionedSequence:R-SCE-5358478] aminocarboxypropyl EEF2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2
output	4 × [SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [EntityWithAccessionedSequence:R-SCE-5367025] Me-diphthine EEF2 [cytosol]
precedingEvent	[Reaction:R-SCE-5358494] DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-5358484
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-5358493] Synthesis of diphthamide-EEF2
(inferredTo)	[Reaction:R-HSA-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2

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