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Entries
Synthesis of diphthamide-EEF2
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authored
[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
dbId
5358493
displayName
Synthesis of diphthamide-EEF2
doi
10.3180/REACT_268628.1
edited
[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
eventOf
[Pathway:R-HSA-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:25723] peptidyl-diphthamide biosynthetic process from peptidyl-histidine
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-5358494] DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 - Homo sapiens
[Reaction:R-HSA-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Homo sapiens
[Reaction:R-HSA-5367022] DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 - Homo sapiens
[Reaction:R-HSA-5358475] DPH6 ligates ammonium to diphthine-EEF2 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5336416] Diphtheria toxin: mode of action and structure
[LiteratureReference:5367012] Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis
[LiteratureReference:5308144] Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2
[LiteratureReference:5336419] Diphtheria toxin
[LiteratureReference:5358468] The biosynthesis and biological function of diphthamide
[LiteratureReference:5643723] The Diphthamide Modification Pathway from Saccharomyces cerevisiae - Revisited
[LiteratureReference:5643869] The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network
[LiteratureReference:5358479] Isolation and properties of the trypsin-derived ADP-ribosyl peptide from diphtheria toxin-modified yeast elongation factor 2
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
Synthesis of diphthamide-EEF2
orthologousEvent
[Pathway:R-PFA-5358493] Synthesis of diphthamide-EEF2 - Plasmodium falciparum
[Pathway:R-SCE-5358493] Synthesis of diphthamide-EEF2 - Saccharomyces cerevisiae
[Pathway:R-SPO-5358493] Synthesis of diphthamide-EEF2 - Schizosaccharomyces pombe
[Pathway:R-DDI-5358493] Synthesis of diphthamide-EEF2 - Dictyostelium discoideum
[Pathway:R-CEL-5358493] Synthesis of diphthamide-EEF2 - Caenorhabditis elegans
[Pathway:R-DME-5358493] Synthesis of diphthamide-EEF2 - Drosophila melanogaster
[Pathway:R-GGA-5358493] Synthesis of diphthamide-EEF2 - Gallus gallus
[Pathway:R-XTR-5358493] Synthesis of diphthamide-EEF2 - Xenopus tropicalis
[Pathway:R-DRE-5358493] Synthesis of diphthamide-EEF2 - Danio rerio
[Pathway:R-SSC-5358493] Synthesis of diphthamide-EEF2 - Sus scrofa
[Pathway:R-BTA-5358493] Synthesis of diphthamide-EEF2 - Bos taurus
[Pathway:R-CFA-5358493] Synthesis of diphthamide-EEF2 - Canis familiaris
[Pathway:R-RNO-5358493] Synthesis of diphthamide-EEF2 - Rattus norvegicus
[Pathway:R-MMU-5358493] Synthesis of diphthamide-EEF2 - Mus musculus
releaseDate
2014-12-11
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5643867] Liu, Shihui, 2014-11-18
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5358493
summation
[Summation:5358495] Eukaryotic elongation factor 2 (EEF2) catalyzes the GTP depe...
Referrals
(hasEvent)
[Pathway:R-HSA-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
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