Reactome | Synthesis of diphthamide-EEF2

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Synthesis of diphthamide-EEF2 Show undefined attributes

authored	[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
dbId	5358493
displayName	Synthesis of diphthamide-EEF2
doi	10.3180/REACT_268628.1
edited	[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
eventOf	[Pathway:R-HSA-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:25723] protein histidyl modification to diphthamide
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5358494] DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 - Homo sapiens [Reaction:R-HSA-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Homo sapiens [Reaction:R-HSA-5367022] DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 - Homo sapiens [Reaction:R-HSA-5358475] DPH6 ligates ammonium to diphthine-EEF2 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5336416] Diphtheria toxin: mode of action and structure [LiteratureReference:5367012] Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis [LiteratureReference:5308144] Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2 [LiteratureReference:5336419] Diphtheria toxin [LiteratureReference:5358468] The biosynthesis and biological function of diphthamide [LiteratureReference:5643723] The Diphthamide Modification Pathway from Saccharomyces cerevisiae - Revisited [LiteratureReference:5643869] The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network [LiteratureReference:5358479] Isolation and properties of the trypsin-derived ADP-ribosyl peptide from diphtheria toxin-modified yeast elongation factor 2
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Synthesis of diphthamide-EEF2
orthologousEvent	[Pathway:R-PFA-5358493] Synthesis of diphthamide-EEF2 - Plasmodium falciparum [Pathway:R-SCE-5358493] Synthesis of diphthamide-EEF2 - Saccharomyces cerevisiae [Pathway:R-SPO-5358493] Synthesis of diphthamide-EEF2 - Schizosaccharomyces pombe [Pathway:R-DDI-5358493] Synthesis of diphthamide-EEF2 - Dictyostelium discoideum [Pathway:R-CEL-5358493] Synthesis of diphthamide-EEF2 - Caenorhabditis elegans [Pathway:R-DME-5358493] Synthesis of diphthamide-EEF2 - Drosophila melanogaster [Pathway:R-GGA-5358493] Synthesis of diphthamide-EEF2 - Gallus gallus [Pathway:R-XTR-5358493] Synthesis of diphthamide-EEF2 - Xenopus tropicalis [Pathway:R-DRE-5358493] Synthesis of diphthamide-EEF2 - Danio rerio [Pathway:R-SSC-5358493] Synthesis of diphthamide-EEF2 - Sus scrofa [Pathway:R-BTA-5358493] Synthesis of diphthamide-EEF2 - Bos taurus [Pathway:R-CFA-5358493] Synthesis of diphthamide-EEF2 - Canis familiaris [Pathway:R-RNO-5358493] Synthesis of diphthamide-EEF2 - Rattus norvegicus [Pathway:R-MMU-5358493] Synthesis of diphthamide-EEF2 - Mus musculus
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5643867] Liu, Shihui, 2014-11-18
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5358493
summation	[Summation:5358495] Eukaryotic elongation factor 2 (EEF2) catalyzes the GTP depe...

Referrals

(hasEvent)

[Pathway:R-HSA-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation

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