Reactome | TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC

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TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10287735
displayName	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
eventOf	[Pathway:R-CFA-5357956] TNFR1-induced NF-kappa-B signaling pathway - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - Canis familiaris [BlackBoxEvent:R-CFA-9793679] LUBAC ubiquitinates RIPK1 at K627 - Canis familiaris [Reaction:R-CFA-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex - Canis familiaris
inferredFrom	[Reaction:R-HSA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Homo sapiens
input	[Complex:R-CFA-5357865] LUBAC [cytosol] [Complex:R-CFA-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
output	[Complex:R-CFA-5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane]
precedingEvent	[BlackBoxEvent:R-CFA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5357904
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5357956] TNFR1-induced NF-kappa-B signaling pathway
(precedingEvent)	[Reaction:R-CFA-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex [Reaction:R-CFA-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG [BlackBoxEvent:R-CFA-9793679] LUBAC ubiquitinates RIPK1 at K627
(inferredTo)	[Reaction:R-HSA-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC