Reactome | SPATA2 links CYLD to LUBAC

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SPATA2 links CYLD to LUBAC Show undefined attributes

authored	[InstanceEdit:9796337] Shamovsky, Veronica, 2022-08-09
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9796688] Shamovsky, Veronica, 2022-08-12
dbId	9796691
displayName	SPATA2 links CYLD to LUBAC
edited	[InstanceEdit:9796551] Shamovsky, Veronica, 2022-08-10
eventOf	[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-741420] CYLD [cytosol] 2 × [Complex:R-HSA-5357865] LUBAC [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-9796351] SPATA2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9796372] SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling [LiteratureReference:9796386] SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes [LiteratureReference:9796402] SPATA2 links CYLD to the TNF-? receptor signaling complex and modulates the receptor signaling outcomes [LiteratureReference:9796345] SPATA2 promotes CYLD activity and regulates TNF-induced NF-?B signaling and cell death
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	SPATA2 links CYLD to LUBAC
orthologousEvent	[Reaction:R-SSC-9796691] SPATA2 links CYLD to LUBAC - Sus scrofa [Reaction:R-BTA-9796691] SPATA2 links CYLD to LUBAC - Bos taurus [Reaction:R-CFA-9796691] SPATA2 links CYLD to LUBAC - Canis familiaris [Reaction:R-RNO-9796691] SPATA2 links CYLD to LUBAC - Rattus norvegicus [Reaction:R-MMU-9796691] SPATA2 links CYLD to LUBAC - Mus musculus
output	[Complex:R-HSA-9796690] CYLD:SPATA2:LUBAC [cytosol]
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9796552] Tu, Hailin, 2022-08-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9796691
summation	[Summation:9796692] Genome-wide siRNA screening identified spermatogenesis-assoc...

Referrals

(precedingEvent)	[Reaction:R-HSA-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex
(hasEvent)	[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling