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Schema
>
BlackBoxEvent
>
Entries
LUBAC ubiquitinates CFLAR at K351, K353
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authored
[InstanceEdit:9793675] Shamovsky, Veronica, 2022-06-23
category
omitted
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:9793997] Shamovsky, Veronica, 2022-06-25
dbId
9793988
displayName
LUBAC ubiquitinates CFLAR at K351, K353
edited
[InstanceEdit:9796659] Shamovsky, Veronica, 2022-08-11
eventOf
[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling - Homo sapiens
input
[Complex:R-HSA-9794013] CFLAR:LUBAC:Ub:UBE2D3 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9793992] Linear ubiquitination of cFLIP induced by LUBAC contributes to TNF?-induced apoptosis
maxDepth
1
modified
[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name
LUBAC ubiquitinates CFLAR at K351, K353
LUBAC ubiquitinates FLIP(l) at K351,K353
orthologousEvent
[BlackBoxEvent:R-SSC-9793988] LUBAC ubiquitinates CFLAR at K351, K353 - Sus scrofa
[BlackBoxEvent:R-BTA-9793988] LUBAC ubiquitinates CFLAR at K351, K353 - Bos taurus
[BlackBoxEvent:R-CFA-9793988] LUBAC ubiquitinates CFLAR at K351, K353 - Canis familiaris
[BlackBoxEvent:R-RNO-9793988] LUBAC ubiquitinates CFLAR at K351, K353 - Rattus norvegicus
[BlackBoxEvent:R-MMU-9793988] LUBAC ubiquitinates CFLAR at K351, K353 - Mus musculus
output
[Complex:R-HSA-5357865] LUBAC [cytosol]
[EntityWithAccessionedSequence:R-HSA-9794015] M1polyUb-K351,K353-CFLAR(1-480) [cytosol]
[EntityWithAccessionedSequence:R-HSA-8864201] Ub-C86-UBE2L3 [cytosol]
precedingEvent
[Reaction:R-HSA-9794008] LUBAC binds CFLAR - Homo sapiens
releaseDate
2022-09-14
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9796128] D'Eustachio, Peter, 2022-08-05
[InstanceEdit:9796552] Tu, Hailin, 2022-08-10
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9793988
summation
[Summation:9793996] The linear ubiquitin chain assembly complex (LUBAC) is a RIN...
Referrals
(hasEvent)
[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling
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