Reactome | K63polyUb-RIPK1 is deubiquitinated

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K63polyUb-RIPK1 is deubiquitinated Show undefined attributes

authored	[InstanceEdit:5692499] Shamovsky, Veronica, 2015-05-12
catalystActivity	[CatalystActivity:5357880] K63-linked deubiquitinase activity of RIPK1 deubiquitinases [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
dbId	5357845
displayName	K63polyUb-RIPK1 is deubiquitinated
edited	[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
eventOf	[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling - Homo sapiens
input	[Complex:R-HSA-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5357806] Regulation of NF-?B by deubiquitinases [LiteratureReference:5357774] Ubiquitin-specific protease 4 promotes TNF-?-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma [LiteratureReference:5357906] Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1 [LiteratureReference:5357830] De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF [LiteratureReference:5357741] CYLD deubiquitinates RIP1 in the TNF?-induced necrosome to facilitate kinase activation and programmed necrosis [LiteratureReference:5357852] NEMO inhibits programmed necrosis in an NF?B-independent manner by restraining RIP1 [LiteratureReference:5357808] NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling [LiteratureReference:9816090] The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-?B signaling [LiteratureReference:9816092] OTUD1 deubiquitinase regulates NF-?B- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	K63polyUb-RIPK1 is deubiquitinated
orthologousEvent	[BlackBoxEvent:R-GGA-5357845] K63polyUb-RIPK1 is deubiquitinated - Gallus gallus [BlackBoxEvent:R-DRE-5357845] K63polyUb-RIPK1 is deubiquitinated - Danio rerio [BlackBoxEvent:R-SSC-5357845] K63polyUb-RIPK1 is deubiquitinated - Sus scrofa [BlackBoxEvent:R-BTA-5357845] K63polyUb-RIPK1 is deubiquitinated - Bos taurus [BlackBoxEvent:R-CFA-5357845] K63polyUb-RIPK1 is deubiquitinated - Canis familiaris [BlackBoxEvent:R-RNO-5357845] K63polyUb-RIPK1 is deubiquitinated - Rattus norvegicus [BlackBoxEvent:R-MMU-5357845] K63polyUb-RIPK1 is deubiquitinated - Mus musculus
output	[Complex:R-HSA-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5357745] Positive regulation by 'CLIP3 [cytosol]' [NegativeRegulation:R-HSA-5357923] Negative regulation by 'p-S418-CYLD [cytosol]'
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5683087] Gillespie, Marc E, 2015-03-11 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5357845
summation	[Summation:5364135] K63-deubiquitination of RIP1 abolishes its ability to activa...
updateTrackers	[UpdateTracker:9846935] Update Tracker - [BlackBoxEvent:5357845] K63polyUb-RIPK1 is deubiquitinated - v83:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9846935] Update Tracker - [BlackBoxEvent:5357845] K63polyUb-RIPK1 is deubiquitinated - v83:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-5357905] Regulation of TNFR1 signaling

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