Reactome | TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]

Schema > Complex > Entries

TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:5357912] ubiquitin-protein transferase activity of TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-HSA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Homo sapiens
created	[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
dbId	5357866
displayName	TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
hasComponent	[CandidateSet:R-HSA-5357900] BIRC2,3,4 [cytosol] [Complex:R-HSA-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - Mus musculus [Complex:R-RNO-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - Canis familiaris [Complex:R-BTA-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - Bos taurus [Complex:R-SSC-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - Sus scrofa [Complex:R-DRE-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - Danio rerio [Complex:R-XTR-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - Gallus gallus
isChimeric	false
literatureReference	[LiteratureReference:5357891] Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation
maxDepth	6
memberOf	[DefinedSet:R-HSA-5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9794240] Shamovsky, Veronica, 2022-06-30
name	TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3
producedByEvent	[Reaction:R-HSA-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) - Homo sapiens [BlackBoxEvent:R-HSA-5357845] K63polyUb-RIPK1 is deubiquitinated - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5357866
updateTrackers	[UpdateTracker:9928639] Update Tracker - [Complex:5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - v91:[updateContainedComponent] [UpdateTracker:9903332] Update Tracker - [Complex:5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - v80:[updateContainedComponent] [UpdateTracker:9904412] Update Tracker - [Complex:5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - v82:[modifyName, updateContainedComponent] [UpdateTracker:9894750] Update Tracker - [Complex:5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - v57:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9928639] Update Tracker - [Complex:5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - v91:[updateContainedComponent] [UpdateTracker:9903332] Update Tracker - [Complex:5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - v80:[updateContainedComponent] [UpdateTracker:9904412] Update Tracker - [Complex:5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - v82:[modifyName, updateContainedComponent] [UpdateTracker:9894750] Update Tracker - [Complex:5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - v57:[updateContainedComponent]
(hasMember)	[DefinedSet:R-HSA-5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane]
(output)	[Reaction:R-HSA-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) [BlackBoxEvent:R-HSA-5357845] K63polyUb-RIPK1 is deubiquitinated
(input)	[BlackBoxEvent:R-HSA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1
(physicalEntity)	[CatalystActivity:5357912] ubiquitin-protein transferase activity of TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]

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