Reactome | K63polyUb-RIPK1 is deubiquitinated

Schema > BlackBoxEvent > Entries

K63polyUb-RIPK1 is deubiquitinated Show undefined attributes

catalystActivity	[CatalystActivity:10513301] K63-linked deubiquitinase activity of RIPK1 deubiquitinases [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10513307
displayName	K63polyUb-RIPK1 is deubiquitinated
eventOf	[Pathway:R-SSC-5357905] Regulation of TNFR1 signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-5357845] K63polyUb-RIPK1 is deubiquitinated - Homo sapiens
input	[Complex:R-SSC-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	K63polyUb-RIPK1 is deubiquitinated
output	[Complex:R-SSC-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] [DefinedSet:R-SSC-113595] Ub [cytosol]
precedingEvent	[BlackBoxEvent:R-SSC-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Sus scrofa
regulatedBy	[PositiveRegulation:10513308] Positive regulation by 'CLIP3 [cytosol]' [NegativeRegulation:10513309] Negative regulation by 'p-S418-CYLD [cytosol]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-5357845
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5357905] Regulation of TNFR1 signaling
(inferredTo)	[BlackBoxEvent:R-HSA-5357845] K63polyUb-RIPK1 is deubiquitinated

Cite Us!