Reactome | NR1H4 binds DCA, CDCA, LCHA

Schema > Reaction > Entries

NR1H4 binds DCA, CDCA, LCHA Show undefined attributes

authored	[InstanceEdit:5340205] Jassal, Bijay, 2014-03-12
catalystActivity	[CatalystActivity:9917215] bile acid nuclear receptor activity of NR1H4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5340205] Jassal, Bijay, 2014-03-12
dbId	5340195
displayName	NR1H4 binds DCA, CDCA, LCHA
edited	[InstanceEdit:5340205] Jassal, Bijay, 2014-03-12
eventOf	[Pathway:R-HSA-159418] Recycling of bile acids and salts - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1989746] Expression of CYP7A1 - Homo sapiens [Reaction:R-HSA-5340251] NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 - Homo sapiens [Reaction:R-HSA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Homo sapiens [Reaction:R-HSA-192051] CYP7A1 7-hydroxylates CHOL - Homo sapiens [Reaction:R-HSA-192065] CYP7B1 7-hydroxylates 25OH-CHOL - Homo sapiens [Reaction:R-HSA-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Homo sapiens
input	[DefinedSet:R-ALL-5340249] DCA,CDCA,LCHA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5340228] NR1H4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5340187] Bile acids: natural ligands for an orphan nuclear receptor [LiteratureReference:444825] Identification of a nuclear receptor for bile acids [LiteratureReference:5340192] Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation [LiteratureReference:5340252] Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis [LiteratureReference:5340220] Endocrine functions of bile acids [LiteratureReference:5340210] FXR, a multipurpose nuclear receptor [LiteratureReference:5340256] Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump [LiteratureReference:5340271] Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	NR1H4 binds DCA, CDCA, LCHA FXR binds bile acids
orthologousEvent	[Reaction:R-CEL-5340195] NR1H4 binds DCA, CDCA, LCHA - Caenorhabditis elegans [Reaction:R-DME-5340195] NR1H4 binds DCA, CDCA, LCHA - Drosophila melanogaster [Reaction:R-GGA-5340195] NR1H4 binds DCA, CDCA, LCHA - Gallus gallus [Reaction:R-XTR-5340195] NR1H4 binds DCA, CDCA, LCHA - Xenopus tropicalis [Reaction:R-DRE-5340195] NR1H4 binds DCA, CDCA, LCHA - Danio rerio [Reaction:R-SSC-5340195] NR1H4 binds DCA, CDCA, LCHA - Sus scrofa [Reaction:R-BTA-5340195] NR1H4 binds DCA, CDCA, LCHA - Bos taurus [Reaction:R-CFA-5340195] NR1H4 binds DCA, CDCA, LCHA - Canis familiaris [Reaction:R-RNO-5340195] NR1H4 binds DCA, CDCA, LCHA - Rattus norvegicus [Reaction:R-MMU-5340195] NR1H4 binds DCA, CDCA, LCHA - Mus musculus
output	[Complex:R-HSA-5340186] NR1H4:DCA,CDCA,LCHA [nucleoplasm]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5674208] D'Eustachio, Peter, 2015-02-11 [InstanceEdit:9917333] Hill, David P, 2024-08-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5340195
summation	[Summation:5340176] The nuclear orphan protein bile acid receptor aka farnesoid ...
updateTrackers	[UpdateTracker:9919429] Update Tracker - [Reaction:5340195] NR1H4 binds DCA, CDCA, LCHA - v90:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9919429] Update Tracker - [Reaction:5340195] NR1H4 binds DCA, CDCA, LCHA - v90:[removeCatalystActivity]
(precedingEvent)	[BlackBoxEvent:R-HSA-1989746] Expression of CYP7A1 [Reaction:R-HSA-5340251] NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 [Reaction:R-HSA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated [Reaction:R-HSA-192051] CYP7A1 7-hydroxylates CHOL [Reaction:R-HSA-192065] CYP7B1 7-hydroxylates 25OH-CHOL [Reaction:R-HSA-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol
(hasEvent)	[Pathway:R-HSA-159418] Recycling of bile acids and salts

Cite Us!