Reactome | 27-hydroxycholesterol is 7alpha-hydroxylated

Schema > Reaction > Entries

27-hydroxycholesterol is 7alpha-hydroxylated Show undefined attributes

authored	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity	[CatalystActivity:192095] oxysterol 7-alpha-hydroxylase activity of Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
dbId	191972
displayName	27-hydroxycholesterol is 7alpha-hydroxylated
edited	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
eventOf	[Pathway:R-HSA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Homo sapiens
followingEvent	[Reaction:R-HSA-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Homo sapiens
input	[SimpleEntity:R-ALL-176617] 27HCHOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191992] Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	27-hydroxycholesterol is 7alpha-hydroxylated 27-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,27-triol + H2O + NADP+
orthologousEvent	[Reaction:R-GGA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Gallus gallus [Reaction:R-XTR-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Xenopus tropicalis [Reaction:R-DRE-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Danio rerio [Reaction:R-SSC-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Sus scrofa [Reaction:R-BTA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Bos taurus [Reaction:R-CFA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Canis familiaris [Reaction:R-RNO-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Rattus norvegicus [Reaction:R-MMU-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Mus musculus
output	[SimpleEntity:R-ALL-192194] Cholest-5-ene-3beta,7alpha,27-triol [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-5340195] NR1H4 binds DCA, CDCA, LCHA - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5340418] Negative regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
revised	[InstanceEdit:5674206] Jassal, Bijay, 2015-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-191972
summation	[Summation:193810] 27-hydroxycholesterol, NADPH + H+, and O2 react to form chol...
updateTrackers	[UpdateTracker:9786376] Update Tracker - [Reaction:191972] 27-hydroxycholesterol is 7alpha-hydroxylated - v49:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9786376] Update Tracker - [Reaction:191972] 27-hydroxycholesterol is 7alpha-hydroxylated - v49:[addRegulator]
(hasEvent)	[Pathway:R-HSA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(precedingEvent)	[Reaction:R-HSA-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one