Reactome | SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol

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SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:194157] D'Eustachio, P, 2007-03-09 21:29:31
catalystActivity	[CatalystActivity:194178] bile acid:sodium symporter activity of SLC10A2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:194163] D'Eustachio, P, 2007-03-09 21:33:16
dbId	194187
displayName	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol
edited	[InstanceEdit:194157] D'Eustachio, P, 2007-03-09 21:29:31
eventOf	[Pathway:R-HSA-159418] Recycling of bile acids and salts - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9733973] Bile salts bind FABP6 - Homo sapiens
input	[DefinedSet:R-ALL-192483] bile salts and acids [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:194094] Bile salt transporters: molecular characterization, function, and regulation [LiteratureReference:193474] Enterohepatic bile salt transporters in normal physiology and liver disease [LiteratureReference:5625194] Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol Co-transport (influx) of bile salts and acids and sodium ions by ASBT
orthologousEvent	[Reaction:R-CEL-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-DME-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-GGA-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Gallus gallus [Reaction:R-XTR-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-DRE-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Danio rerio [Reaction:R-SSC-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Sus scrofa [Reaction:R-BTA-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Bos taurus [Reaction:R-CFA-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Canis familiaris [Reaction:R-RNO-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Rattus norvegicus [Reaction:R-MMU-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Mus musculus
output	[DefinedSet:R-ALL-194156] bile salts and acids [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
precedingEvent	[Reaction:R-HSA-5340195] NR1H4 binds DCA, CDCA, LCHA - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5340412] Positive regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
revised	[InstanceEdit:5625191] Swaan, Peter, 2014-10-03 [InstanceEdit:5674206] Jassal, Bijay, 2015-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-194187
summation	[Summation:194174] A molecule of extracellular bile salt or bile acid (cholate,...
updateTrackers	[UpdateTracker:9776069] Update Tracker - [Reaction:194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - v78:[add_removeOutput, modifyText, removeInput] [UpdateTracker:9786518] Update Tracker - [Reaction:194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - v49:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9785769] Update Tracker - [Reaction:194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - v51:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776069] Update Tracker - [Reaction:194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - v78:[add_removeOutput, modifyText, removeInput] [UpdateTracker:9786518] Update Tracker - [Reaction:194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - v49:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9785769] Update Tracker - [Reaction:194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - v51:[add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-159418] Recycling of bile acids and salts
(precedingEvent)	[BlackBoxEvent:R-HSA-9733973] Bile salts bind FABP6

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