Reactome | Recycling of bile acids and salts

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Recycling of bile acids and salts Show undefined attributes

authored	[InstanceEdit:159408] Jassal, B, 2005-03-09 13:42:30
created	[InstanceEdit:159408] Jassal, B, 2005-03-09 13:42:30
dbId	159418
displayName	Recycling of bile acids and salts
edited	[InstanceEdit:194157] D'Eustachio, P, 2007-03-09 21:29:31
eventOf	[Pathway:R-HSA-194068] Bile acid and bile salt metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24849] bile acid and bile salt transport
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5340195] NR1H4 binds DCA, CDCA, LCHA - Homo sapiens [Reaction:R-HSA-5340251] NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 - Homo sapiens [Reaction:R-HSA-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Homo sapiens [BlackBoxEvent:R-HSA-9733973] Bile salts bind FABP6 - Homo sapiens [BlackBoxEvent:R-HSA-9733969] Bile salts dissociate from FABP6 - Homo sapiens [Reaction:R-HSA-194153] ABCC3 transports bile salts from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-9733964] SLC51A:SLC51B transports bile salts from cytosol to extracellular region - Homo sapiens [BlackBoxEvent:R-HSA-9733545] Bile salts and acids bind ALB - Homo sapiens [BlackBoxEvent:R-HSA-9733960] Bile salts and acids dissociate from ALB - Homo sapiens [Reaction:R-HSA-194121] SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-194130] Transport (influx) of bile salts and acids by OATP-A - Homo sapiens [Reaction:R-HSA-194083] SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-194079] SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-8873850] STARD5 binds DCA, LCA - Homo sapiens [Reaction:R-HSA-159425] Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) - Homo sapiens [Reaction:R-HSA-159431] Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine - Homo sapiens [Reaction:R-HSA-193362] ABCB11 transports bile salts from cytosol to extracellular region - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-12-08
literatureReference	[LiteratureReference:159406] Measurement and subcellular distribution of choloyl-CoA synthetase and bile acid-CoA:amino acid N-acyltransferase activities in rat liver [LiteratureReference:159413] Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Recycling of bile acids and salts
orthologousEvent	[Pathway:R-MMU-159418] Recycling of bile acids and salts - Mus musculus [Pathway:R-RNO-159418] Recycling of bile acids and salts - Rattus norvegicus [Pathway:R-CFA-159418] Recycling of bile acids and salts - Canis familiaris [Pathway:R-BTA-159418] Recycling of bile acids and salts - Bos taurus [Pathway:R-SSC-159418] Recycling of bile acids and salts - Sus scrofa [Pathway:R-DRE-159418] Recycling of bile acids and salts - Danio rerio [Pathway:R-XTR-159418] Recycling of bile acids and salts - Xenopus tropicalis [Pathway:R-GGA-159418] Recycling of bile acids and salts - Gallus gallus [Pathway:R-DME-159418] Recycling of bile acids and salts - Drosophila melanogaster [Pathway:R-CEL-159418] Recycling of bile acids and salts - Caenorhabditis elegans [Pathway:R-DDI-159418] Recycling of bile acids and salts - Dictyostelium discoideum [Pathway:R-SPO-159418] Recycling of bile acids and salts - Schizosaccharomyces pombe [Pathway:R-SCE-159418] Recycling of bile acids and salts - Saccharomyces cerevisiae [Pathway:R-PFA-159418] Recycling of bile acids and salts - Plasmodium falciparum
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26 [InstanceEdit:9963240] D'Eustachio, Peter, 2025-08-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-159418
summation	[Summation:159405] Of the 20-40 grams of bile salts released daily by the liver...
updateTrackers	[UpdateTracker:9782098] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v59:[updateContainedRLE] [UpdateTracker:9775757] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v78:[addHasEvent, updateContainedRLE] [UpdateTracker:9775449] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v79:[updateContainedRLE] [UpdateTracker:9785837] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v51:[updateContainedRLE] [UpdateTracker:9785528] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v52:[addHasEvent, updateContainedRLE] [UpdateTracker:9790050] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v35:[updateContainedRLE] [UpdateTracker:9782911] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v58:[addHasEvent] [UpdateTracker:9786627] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v49:[updateContainedRLE] [UpdateTracker:9791069] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v32:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-194068] Bile acid and bile salt metabolism

(updatedInstance)

[UpdateTracker:9782098] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v59:[updateContainedRLE]
[UpdateTracker:9775757] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v78:[addHasEvent, updateContainedRLE]
[UpdateTracker:9775449] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v79:[updateContainedRLE]
[UpdateTracker:9785837] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v51:[updateContainedRLE]
[UpdateTracker:9785528] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v52:[addHasEvent, updateContainedRLE]
[UpdateTracker:9790050] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v35:[updateContainedRLE]
[UpdateTracker:9782911] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v58:[addHasEvent]
[UpdateTracker:9786627] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v49:[updateContainedRLE]
[UpdateTracker:9791069] Update Tracker - [Pathway:159418] Recycling of bile acids and salts - v32:[updateContainedRLE]

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