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Schema
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Reaction
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Entries
DT fragment A ADP-ribosylates target cell EEF
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authored
[InstanceEdit:5339551] D'Eustachio, Peter, 2014-03-04
catalystActivity
[CatalystActivity:5336414] NAD+-diphthamide ADP-ribosyltransferase activity of DT(33-225) [cytosol]
catalystActivityReference
[CatalystActivityReference:9644061] NAD+-diphthamide ADP-ribosyltransferase activity of DT(33-225) [cytosol] Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:5336423] D'Eustachio, Peter, 2014-03-02
crossReference
[DatabaseIdentifier:12020821] Mondo:0005504
dbId
5336421
disease
[Disease:5334089] diphtheria
displayName
DT fragment A ADP-ribosylates target cell EEF
edited
[InstanceEdit:5339551] D'Eustachio, Peter, 2014-03-04
eventOf
[Pathway:R-HSA-5336415] Uptake and function of diphtheria toxin - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-156901] EEF2 [cytosol]
[SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5336416] Diphtheria toxin: mode of action and structure
[LiteratureReference:5339494] Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin
[LiteratureReference:5334758] ADP-ribosylation of elongation factor 2 by diphtheria toxin. Isolation and properties of the novel ribosyl-amino acid and its hydrolysis products
[LiteratureReference:5334749] ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
DT fragment A ADP-ribosylates target cell EEF
output
[EntityWithAccessionedSequence:R-HSA-5334764] ADP-ribo-EEF2 [cytosol]
[SimpleEntity:R-ALL-197277] NAM [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-5336420] DT fragment B transports DT fragment A from target cell endosome membrane - Homo sapiens
[Reaction:R-HSA-5358475] DPH6 ligates ammonium to diphthine-EEF2 - Homo sapiens
relatedSpecies
[Species:5333948] Corynephage beta
releaseDate
2014-12-11
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5643873] Liu, Shihui, 2014-11-18
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5336421
summation
[Summation:5339550] Target cell elongation factor 2 (EEF2) is ADP-ribosylated in...
Referrals
(hasEvent)
[Pathway:R-HSA-5336415] Uptake and function of diphtheria toxin
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