DT fragment A ADP-ribosylates target cell EEF

Stable Identifier
R-HSA-5336421
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Corynephage beta
Compartment
cytosol
ReviewStatus
5/5
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DT fragment A ADP-ribosylates target cell EEF
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Target cell elongation factor 2 (EEF2) is ADP-ribosylated in a reaction catalyzed by cytosolic diphtheria toxin fragment A (DT A), inactivating it (Honjo et al. 1971; Van Ness et al. 1980a,b). The loss of EEF2 activity blocks target cell protein synthesis, and a small number of DT A molecules are capable of inactivating sufficient EEF2 to cause target cell death (Collier 1975).
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Catalyst Activity

NAD+-diphthamide ADP-ribosyltransferase activity of DT(33-225) [cytosol]

Physical Entity
DT(33-225) [cytosol] (Corynephage beta)
Activity
NAD+-diphthamide ADP-ribosyltransferase activity (GO:0047286)
Disease
Name Identifier Synonyms
diphtheria DOID:11405 corynebacterium infection
Authored
D'Eustachio, P  (2014-03-05)
Reviewed
Liu, S  (2014-11-19)
Created
D'Eustachio, P  (2014-03-03)
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