DT fragment A ADP-ribosylates target cell EEF

Stable Identifier
R-HSA-5336421
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Corynephage beta
Compartment
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Target cell elongation factor 2 (EEF2) is ADP-ribosylated in a reaction catalyzed by cytosolic diphtheria toxin fragment A (DT A), inactivating it (Honjo et al. 1971; Van Ness et al. 1980a,b). The loss of EEF2 activity blocks target cell protein synthesis, and a small number of DT A molecules are capable of inactivating sufficient EEF2 to cause target cell death (Collier 1975).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD+-diphthamide ADP-ribosyltransferase activity of DT(33-225) [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
diphtheria 11405 corynebacterium infection
Authored
Reviewed
Created
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