Reactome | DT fragment B transports DT fragment A from target cell endosome membrane

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DT fragment B transports DT fragment A from target cell endosome membrane Show undefined attributes

authored	[InstanceEdit:5339551] D'Eustachio, Peter, 2014-03-04
catalystActivity	[CatalystActivity:5336418] protein transmembrane transporter activity of DT:HBEGF:CD9 [endocytic vesicle membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:24337] endocytic vesicle membrane
created	[InstanceEdit:5336423] D'Eustachio, Peter, 2014-03-02
crossReference	[DatabaseIdentifier:12020821] Mondo:0005504
dbId	5336420
disease	[Disease:5334089] diphtheria
displayName	DT fragment B transports DT fragment A from target cell endosome membrane
edited	[InstanceEdit:5339551] D'Eustachio, Peter, 2014-03-04
eventOf	[Pathway:R-HSA-5336415] Uptake and function of diphtheria toxin - Homo sapiens
followingEvent	[Reaction:R-HSA-5336421] DT fragment A ADP-ribosylates target cell EEF - Homo sapiens
input	[Complex:R-HSA-5334780] DT:HBEGF:CD9 [endocytic vesicle membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5334783] Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process [LiteratureReference:5339510] The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DT fragment B transports DT fragment A from target cell endosome membrane
output	[EntityWithAccessionedSequence:R-HSA-5334774] CD9 [endocytic vesicle membrane] [EntityWithAccessionedSequence:R-CPH-5334084] DT(226-567) [endocytic vesicle membrane] [EntityWithAccessionedSequence:R-CPH-5334080] DT(33-225) [cytosol] [EntityWithAccessionedSequence:R-HSA-5334776] HBEGF(20-208) [endocytic vesicle membrane]
precedingEvent	[BlackBoxEvent:R-HSA-5336413] DT:HBEGF:CD9 is transported from clathrin-coated vesicle to endosome - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5336424] Positive regulation by 'H+ [endocytic vesicle lumen]' [PositiveRegulation:R-HSA-5339491] Positive regulation by 'TXNRD1 [cytosol]' [PositiveRegulation:R-HSA-5339496] Positive regulation by 'HSP90AA1 [cytosol]' [PositiveRegulation:R-HSA-5339504] Positive regulation by 'HSP90AB1 [cytosol]'
regulationReference	[RegulationReference:9641971] Positive regulation by 'HSP90AB1 [cytosol]' The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex [RegulationReference:9642356] Positive regulation by 'HSP90AA1 [cytosol]' The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex [RegulationReference:9642622] Positive regulation by 'TXNRD1 [cytosol]' The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex
relatedSpecies	[Species:5333948] Corynephage beta
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5643873] Liu, Shihui, 2014-11-18
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5336420
summation	[Summation:5339556] The normal process of acidification of the endocytic vesicle...

Referrals

(hasEvent)	[Pathway:R-HSA-5336415] Uptake and function of diphtheria toxin
(precedingEvent)	[Reaction:R-HSA-5336421] DT fragment A ADP-ribosylates target cell EEF