Reactome | Uptake and function of diphtheria toxin

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Uptake and function of diphtheria toxin Show undefined attributes

authored	[InstanceEdit:5339551] D'Eustachio, Peter, 2014-03-04
created	[InstanceEdit:5336423] D'Eustachio, Peter, 2014-03-02
crossReference	[DatabaseIdentifier:12020821] Mondo:0005504
dbId	5336415
disease	[Disease:5334089] diphtheria
displayName	Uptake and function of diphtheria toxin
doi	10.3180/REACT_268571.1
edited	[InstanceEdit:5339551] D'Eustachio, Peter, 2014-03-04
eventOf	[Pathway:R-HSA-5339562] Uptake and actions of bacterial toxins - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5336417] DT A:B binds HBEGF and CD9 on the target cell surface - Homo sapiens [BlackBoxEvent:R-HSA-5336422] Clathrin-mediated endocytosis of DT:HBEGF:CD9 - Homo sapiens [BlackBoxEvent:R-HSA-5336413] DT:HBEGF:CD9 is transported from clathrin-coated vesicle to endosome - Homo sapiens [BlackBoxEvent:R-HSA-5336420] DT fragment B transports DT fragment A from target cell endosome membrane - Homo sapiens [Reaction:R-HSA-5336421] DT fragment A ADP-ribosylates target cell EEF - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:5336416] Diphtheria toxin: mode of action and structure [LiteratureReference:5334783] Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process [LiteratureReference:5336419] Diphtheria toxin
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Uptake and function of diphtheria toxin
relatedSpecies	[Species:5333948] Corynephage beta
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5643873] Liu, Shihui, 2014-11-18
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5336415
summation	[Summation:5339555] Diphtheria is a serious, often fatal human disease associate...
updateTrackers	[UpdateTracker:9775138] Update Tracker - [Pathway:5336415] Uptake and function of diphtheria toxin - v80:[updateContainedRLE]

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(updatedInstance)	[UpdateTracker:9775138] Update Tracker - [Pathway:5336415] Uptake and function of diphtheria toxin - v80:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-5339562] Uptake and actions of bacterial toxins

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