Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes

Stable Identifier
R-HSA-5229348
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes
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Transcription of WNT genes is repressed in the absence of WNT signal by TLE:HDAC complexes (reviewed in Cinnamon and Paroush, 2008; Saito-Diaz et al, 2013). Represssion may also be mediated by CTBP proteins binding to TCF7L1 and TCF7L3 (Duval et al, 2000; Cuilliere-Dartigues et al, 2006; Tang et al, 2008).
Literature References
PubMed ID Title Journal Year
18721877 Context-dependent regulation of Groucho/TLE-mediated repression

Paroush, Z, Cinnamon, E

Curr. Opin. Genet. Dev. 2008
10919662 The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines

Rolland, S, Duval, A, Thomas, G, Tubacher, E, Hamelin, R, Bui, H

Cancer Res. 2000
23256519 The way Wnt works: Components and mechanism

Wang, X, Wallace, HA, Page-McCaw, A, Lee, E, Thorne, CA, Chen, TW, Saito-Diaz, K

Growth Factors 2013
16547505 TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription

Duval, A, El-Bchiri, J, Cuilliere-Dartigues, P, Hamelin, R, Fontanges, P, Buhard, O, Fléjou, JF, Krimi, A

Oncogene 2006
18621708 A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

Dodge, M, Lum, L, Gundapaneni, D, Michnoff, C, Tang, W, Roth, M

Proc. Natl. Acad. Sci. U.S.A. 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
TCF7L2/TCF7L1:CTBPs [nucleoplasm] (Homo sapiens)
Active Unit
CTBPs [nucleoplasm]
Regulator
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
Active Unit
HDAC1 [nucleoplasm]
Authored
Rothfels, K  (2014-01-14)
Reviewed
Rajakulendran, N  (2014-01-22)
Created
Rothfels, K  (2014-01-17)
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