Reactome | NoRC:HDAC:DNMT methylates cytosine of the rRNA genes

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NoRC:HDAC:DNMT methylates cytosine of the rRNA genes Show undefined attributes

authored	[InstanceEdit:5227039] May, B, 2014-01-09
catalystActivity	[CatalystActivity:427401] DNA-methyltransferase activity of NoRC:pRNA:HDAC:DNMT [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5227491] May, B, 2014-01-09
dbId	5227490
displayName	NoRC:HDAC:DNMT methylates cytosine of the rRNA genes
edited	[InstanceEdit:5227039] May, B, 2014-01-09
eventOf	[Pathway:R-HSA-427413] NoRC negatively regulates rRNA expression - Homo sapiens
followingEvent	[Reaction:R-HSA-427337] MBD2 binds methylcytosine in chromatin - Homo sapiens
inferredFrom	[Reaction:R-MMU-573383] NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes - Mus musculus
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-HSA-3211683] Chromatin (H3K9me2) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:427351] Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells
maxDepth	1
modified	[InstanceEdit:9856088] May, Bruce, 2023-12-10
name	NoRC:HDAC:DNMT methylates cytosine of the rRNA genes
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [Complex:R-HSA-5226877] Chromatin with H3K9me2, 5mC [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-433672] NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5332991] Shiao, YH, 2014-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5227490
summation	[Summation:5227489] From research with human cells (Espada et al. 2007) and infe...
updateTrackers	[UpdateTracker:9864181] Update Tracker - [Reaction:5227490] NoRC:HDAC:DNMT methylates cytosine of the rRNA genes - v88:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9864181] Update Tracker - [Reaction:5227490] NoRC:HDAC:DNMT methylates cytosine of the rRNA genes - v88:[modifyText, removeLiteratureReference]
(precedingEvent)	[Reaction:R-HSA-427337] MBD2 binds methylcytosine in chromatin
(hasEvent)	[Pathway:R-HSA-427413] NoRC negatively regulates rRNA expression
(inferredTo)	[Reaction:R-MMU-573383] NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes

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