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Schema
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Reaction
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Entries
NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes
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authored
[InstanceEdit:565730] May, B, 2010-04-06
catalystActivity
[CatalystActivity:573372] DNA-methyltransferase activity of NoRC:pRNA:Hdac:Dnmt [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:573322] May, B, 2010-04-10
dbId
573383
deleted
[Deleted:9032446] Deletion of instance: 573389
[Deleted:9032440] Deletion of instance: 5334727
displayName
NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes
edited
[InstanceEdit:565730] May, B, 2010-04-06
input
[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm]
[OtherEntity:R-ALL-29428] DNA [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:427357] Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation
[LiteratureReference:427396] The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription
[LiteratureReference:5096481] Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes
[LiteratureReference:427388] Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes
orthologousEvent
[Reaction:R-HSA-5227490] NoRC:HDAC:DNMT methylates cytosine of the rRNA genes - Homo sapiens
output
[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm]
[OtherEntity:R-ALL-212172] DNA containing 5-mC [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-MMU-573376] NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene - Mus musculus
releaseDate
2014-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5332991] Shiao, YH, 2014-02-18
schemaClass
Reaction
species
[Species:48892] Mus musculus
stId
R-MMU-573383
summation
[Summation:580598] Cytosine residues in the main promoter of silenced rRNA gene...
Referrals
(replacementInstances)
[Deleted:9032440] Deletion of instance: 5334727
[Deleted:9032446] Deletion of instance: 573389
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