NoRC:HDAC:DNMT methylates cytosine of the rRNA genes

Stable Identifier
Reaction [transition]
Homo sapiens
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From research with human cells (Majumder et al. 2006, Espada et al. 2007) and inferences from mouse cell models, cytosine residues in the main promoter of silenced rRNA gene copiess are methylated by DNMT1 and DNMT3B. DNMT3B directly binds a triple helix formed by pRNA and the main promoter of rDNA. The methylated cytosines prevent binding of the UBF transcription factor, thus preventing transcription of silenced rRNA gene copies. Histone deacetylation is required for DNA methylation.

Literature References
PubMed ID Title Journal Year
16735507 Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription

Bai, S, Majumder, S, Smith, DS, Datta, J, Jacob, ST, Ghoshal, K

J. Biol. Chem. 2006
17355984 Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells

Längst, G, Fraga, MF, Villar-Garea, A, Esteller, M, Santoro, R, Ballestar, E, Németh, A, Ropero, S, Lopez-Serra, L, Aranda, A, Stockert, JC, Bickmore, W, Espada, J, Juarranz, A, Grummt, I, Orozco, H, Moreno, V

Nucleic Acids Res 2007
Catalyst Activity

DNA-methyltransferase activity of NoRC:pRNA:HDAC:DNMT [nucleoplasm]

Inferred From
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