Reactome | NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3

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NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 Show undefined attributes

authored	[InstanceEdit:427381] May, B, 2009-06-19
catalystActivity	[CatalystActivity:573370] histone deacetylase activity of NoRC:pRNA:HDAC:DNMT [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:433671] May, B, 2009-08-24
dbId	433672
displayName	NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3
edited	[InstanceEdit:427381] May, B, 2009-06-19
eventOf	[Pathway:R-HSA-427413] NoRC negatively regulates rRNA expression - Homo sapiens
followingEvent	[Reaction:R-HSA-5227490] NoRC:HDAC:DNMT methylates cytosine of the rRNA genes - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-573376] NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene - Mus musculus
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-HSA-5226874] Chromatin (H4K5ac, H4K8ac, H4K16ac) [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 Deacetylation of Histone H4 and Dimethylation of Lysine-9 of Histone H3 in Promoter of rRNA Gene
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [SimpleEntity:R-ALL-427486] CH3COO- [nucleoplasm] [Complex:R-HSA-3211683] Chromatin (H3K9me2) [nucleoplasm]
precedingEvent	[Reaction:R-HSA-427409] Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5332991] Shiao, YH, 2014-02-18
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-433672
summation	[Summation:433673] As inferred from mouse cell models, histones in silenced rRN...
updateTrackers	[UpdateTracker:9779700] Update Tracker - [BlackBoxEvent:433672] NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 - v64:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9779700] Update Tracker - [BlackBoxEvent:433672] NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 - v64:[removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-427413] NoRC negatively regulates rRNA expression
(precedingEvent)	[Reaction:R-HSA-5227490] NoRC:HDAC:DNMT methylates cytosine of the rRNA genes
(inferredTo)	[BlackBoxEvent:R-MMU-573376] NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene

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